Exploring the Role of Tissue Microenvironments
The biochemical and biomechanical properties of the cellular microenrivonment play a pivotal role in shaping various biological processes, including cellular behaviour, development, physiology and pathology. In our laboratory, guided by the concept that 'environment dictates behaviour', we explore how cellular and tissue microenvironments influence cell behaviour and fate, particularly during organ development and regeneration, using mammalian skin as a model. Our primary focus is on revealing the principles underlying the interactions between tissue stem cells and their extracellular matrix. Our ultimate research goal is to define and design the microenvironment to manipulate biological processes from outside the cells.
News & Events
Workshop:
"Designer Matrix and Organoid"
2025年1月29日(水)
13:00-18:30
理研BDR神戸
参加登録URL( 1月22日〆切)
https://forms.gle/i6vgrSP7QsX8UkrK9
Published:
An eGFP-Col4a2 mouse model reveals basement membrane dynamics underlying hair follicle morphogenesis
Wuergezhen et al. J Cell Biol. (2025) 224 (2): e202404003
Published:
Dynamic duo: Cell-extracellular matrix interactions in hair follicle development and regeneration
Fujiwara et al. Dev Biol. (2024) 516: 20–34
Posted:
Constructing a Single-Cell Transcriptome Atlas of the Hair Cycle to Decipher Tissue Regeneration Dynamics in Human Skin
Yokota et al. SSRN (2024): https://ssrn.com/abstract=4690956
Funded:
Kohei Omachi has been selected as a JSPS ACT-X program researcher.
大町紘平さんがJST ACT-X(2023)に採択されました。
Multimodal ECM consortium:
Hironobu Fujiwara will lead a 5-year ECM research consortium 'Multimodal ECM (2023-2027)'.
藤原が領域代表を務める学術変革領域研究(A) 「マルチモダルECM」がスタートします。
Contact
2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan
650-0047 神戸市中央区港島南町2-2-3
hironobu.fujiwara[at]riken.jp
Tel: 078-306-3171 (Lab)